Adult: For addition to large volume IV fluids for treatment or prevention of hyponatraemia in patients with restricted or no oral intake. Dose and rate of administration are dependent on patient's needs. Maintenance electrolyte requirements of sodium in parenteral nutrition solutions: 1-2 mEq/kg/24 hours. Monitor serum sodium levels for dosage adjustments.
Reconstitution
Dilute in a larger volume of fluid (e.g. dextrose 5% inj, nutritional admixtures) before administration.
Contraindications
Hypernatraemia, fluid retention, metabolic or respiratory alkalosis, hypocalcaemia.
Special Precautions
Patient with acid-base alterations, oedematous or sodium-retaining state, heart failure, cirrhosis, oliguria, anuria. Patient receiving corticosteroid or corticotropin. Avoid extravasation. Renal and severe hepatic impairment. Elderly. Pregnancy.
Adverse Reactions
Significant: Hypernatraemia; fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states, or pulmonary oedema. Gastrointestinal disorders: Abdominal distention, flatulence. Vascular disorders: Localised phlebitis, thrombosis.
Monitoring Parameters
Monitor serum electrolytes (e.g. sodium, calcium) and serum pH.
Overdosage
Symptoms: Hypernatraemia (excessive administration of sodium); hypokalaemia and metabolic alkalosis (excessive administration of acetate). Management: Discontinue treatment immediately and initiate corrective measures to reduce increased sodium levels and restore acid-base balance if needed.
Drug Interactions
May increase the renal clearance of acidic drugs (e.g. salicylates, barbiturates, tetracyclines). May decrease the renal clearance of basic drugs (e.g. amphetamine, quinidine, pseudoephedrine).
Action
Description: Mechanism of Action: Sodium plays an important role in controlling the total body water and its distribution. Sodium is the main cation in the extracellular fluid and comprises >90% of total cations. Acetate is an alternate source of bicarbonate by metabolic conversion in the liver. Pharmacokinetics: Metabolism: Acetate ion is metabolised in the liver into bicarbonate.